Bleymour (Blair Wainwright x Seymour Skinner)

Some sort of whitish greyish blondish hair, yellow-green eyes, and a skintone that's noticeably darker than Susan but lighter than Seymour\Armin.
Face shape would be somewhere between Boyd's and Seymour's, with somewhat protruding ears.
Lips would be Susan's but slightly larger and fuller.
Nose would be like Boyd's, but the nostrils would be lower, and the upper nose would be somewhat shaped like a quarter of a circle.
Eye shape would be like Susan's and Seymour\Armin's. Their eyelids would be very prominent and also they would have very bushy eyelashes and eyebrows.
They would wear a combination of teal, fuchsia, orange, and lime green with some purple, red, and\or white here or there.
Their hair would be frizzy and somewhat spiky. They tend to either gel it up and away from their eyes, or wear it in some quirky updo.
As toddlers they wear pastel onesies. As kids they wear rather simple clothing in clashing colors, always putting the first thing they find on. As teens and over, their fashion sense gets kinda influenced by some sci-fi movie, and always try to vague-cosplay as the main characters, and rip-off catchphrases from there.

As this is a crossover ship I have to bend the canon a bit. So the first kid, a son named Jacob Amadeus Tamzarian, is born when Blair is 30 and Armin 31. The second kid, a daughter named Emelie Naysha Tamzarian, is born when Blair is 33 and Armin 34.
Jacob is known as Jake. Emelie is known as Emy.
Jake and Emy both have "Steamed Hams" as their favorite food.
They also share Electronica as their favorite music, and Emy has teal as her fave color while Jake has orange.
Their personalities also differ wildly.
Emy's traits: Genius\Neurotic\Shy\Rebellious\Clumsy
Jake's traits: Genius\Brave\Workaholic\Ambitious\Bookworm
It's not surprising that Jake grows up to be a writer of sci-fi bestsellers, and Emy follows her maternal grandparents' way into mad science.